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Articles

Date of Publish: 05/09/2006

Removal of dental amalgam decreases anti-TPO and anti-Tg autoantibodies in patients with autoimmune thyroiditis

Sterzl I, Prochazkova J, Hrda P, Matucha P, Bartova J, Stejskal V. Neuro Endocrinol Lett 2006; 27(Suppl 1): 25-30
The impact of dental amalgam removal on the levels of anti- thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-Tg) antibodies was studied in patients with autoimmune thyroiditis (AT) with and without mercury allergy. Thirty-nine patients with AT were tested by MELISA® for allergy to inorganic mercury. Patients were divided into two groups: Group I (n = 12) with no hypersensitivity to mercury and Group II (n = 27) with hypersensitivity to mercury. Amalgam fillings were removed from the oral cavities of 15 patients with hyperensitivity to mercury (Group IIA) and left in place in the remaining 12 patients (Group
IIB). The laboratory markers of AT, anti-TPO and anti-Tg autoantibodies were
determined in all groups at the beginning of the study and six months later. Compared to levels at the beginning of the study, only patients with mercury hypersensitivity who underwent amalgam replacement (Group IIA) showed a significant decrease in the levels of both anti-Tg (p=0.001) and anti-TPO (p=0.0007) autoantibodies. The levels of autoantibodies in patients with or without mercury hypersensitivity (Group I and Group IIB) who did not replace amalgam did not change.

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